Hyperbaric Oxygen Therapy: Evidence and Considerations for Healthy Aging
An Analytical Review of Trends and Caveats
LetsGo Care Editorial
Hyperbaric Oxygen Therapy: Evidence and Considerations for Healthy Aging
Interest in hyperbaric oxygen therapy for longevity continues to grow, yet the supporting human data require careful contextualization.
Hyperbaric oxygen therapy involves breathing concentrated oxygen in a pressurized environment, a modality originally developed for decompression illness that has attracted attention in wellness circles for potential effects on cellular repair and inflammation.
In this article
- Proposed Mechanisms Relevant to Aging
- Current Human Evidence on Aging Markers
- Practical Access and guide Variability
- Key Uncertainties and Research Gaps
Proposed Mechanisms Relevant to Aging
Increased oxygen partial pressure may influence hypoxia-inducible factors and mitochondrial function, though the precise pathways linking these changes to measurable longevity outcomes in humans remain incompletely mapped and context-dependent.
Current Human Evidence on Aging Markers
Small trials have reported shifts in telomere length or senescent cell burden under specific guides, yet replication is limited, sample sizes are modest, and effect sizes vary widely across populations and dosing regimens.
Practical Access and guide Variability
Session parameters differ substantially between facilities, with pressures, durations, and frequencies not standardized for aging applications, making direct comparisons across studies challenging and individual responses difficult to predict.
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